Unique Features

  • Complementary test to the established IDS-iSYS 25-Hydroxy Vitamin D – dual testing of both analytes from a single sample tube, aiding management of CKD patients
  • Excellent assay sensitivity and precision – provides consistent and reproducible results required for monitoring therapeutic monitoring
  • Broad assay range – eliminates the need for dilution and re-running of high concentration samples
  • Cost effective solution
  • Increase productivity
  • One serum sample for entire panel

The IDS-iSYS Intact PTH assay is intended for the quantitative determination of PTH in human serum or plasma on the IDS-iSYS Multi-Discipline Automated System.

Results are to be used in conjunction with other clinical and laboratory data to assist the clinician in the differential diagnosis of hypercalcemia and hypocalcaemia resulting from disorders of calcium metabolism.

Parathyroid hormone (PTH) is a polypeptide hormone of 84 amino acids secreted by the parathyroid glands. Synthesis of PTH is governed by direct negative feedback of ionised calcium on the parathyroid tissues 1.

A fall in serum calcium stimulates PTH release, which acts on the kidneys to promote calcium reabsorption and 1,25-dihydroxyvitamin D production. This stimulates bone resorption, restoring serum calcium levels to physiologically acceptable levels 2. Measurement of circulating PTH is of particular value in the differential diagnosis of hypercalcaemia, improving the clinical discrimination between patients with hyperparathyroidism and those with hypercalcaemia of malignancy (HCM).

Hyperparathyroidism may be secondary to intestinal malabsorption of calcium or vitamin D deficiency, and is a consistent feature of chronic kidney disease (CKD) 3.

1. Potts JT. Parathyroid Hormone: Past and present. J Endocrinology (2005) 187: 311-325.

2. Bringhurst FR. et al: Circulating forms of parathyroid hormone: Peeling back the onion. Clin Chemistry (2003) 49: 1973-1975.

3. Komaba H. et al. Critical issues of PTH assays in CKD. Bone (2009) 45: 514-518.