Animal Research
IDS provides assays to support determination of markers of bone and cartilage degradation in animal models.
Bone and Cartilage Metabolism Markers for use in Translational Research
Immunodiagnostic Systems Limited (referred to hereafter as IDS) offers a complete panel of bone and cartilage turnover markers reflecting the processes in formation and degradation1. These markers are suitable for cell culture (e.g. ex vivo cultures of bone and/or cartilage, in vitro osteoclast or osteoblasts) and in different animal species and specimens ranging from urine or blood tests to rodents and mammals.
Bone turnover, also called bone remodelling, is a dynamic, lifelong process in which old bone is removed from the skeleton and new bone is added. The continual process of adult bone remodelling is essential for the maintenance of bone mass and skeletal micro-architecture. Osteoporosis is a disease characterised by low bone density and reduced structural strength of the bone leading to increased risk of bone fracture.
Bone resorption: C-terminal telopeptides (CTX-I) assays are available for cell culture, animal urine and serum samples.
Bone formation markers: Procollagen type I propeptides (PINP) is available for cell culture and rodent serum; Osteocalcin for serum samples and osteoclast marker (tartrate-resistant-acid phosphatase 5b (TRAcP5b)) are available for use with cell culture and animal serum samples.
Cartilage is a connective tissue found in many areas of the body including joints between bones (articular cartilage). Individuals whose cartilage is affected suffer from joint disease (arthritis) which is mainly degenerative and causes arthritis/osteoarthritis (OA) but also inflammatory arthritis including rheumatoid arthritis (RA) and ankylosing spondylitis (AS).
For the quantification of cartilage, degradation products of C-terminal telopeptides of type II collagen (CTX-II) assays are available for tissue culture supernatant, animal serum, urine and synovial fluid. Cartilage turnover can be investigated with cartilage oligomeric matrix protein (COMP) in serum and synovial fluid animal samples.
IDS is committed to providing highly accurate and reproducible assays for the measurement of bone and cartilage metabolism, thus ensuring reliability of results. Find out more about our Animal Research product panel by visiting the product pages below:
- RatLaps™ (CTX-I) EIA
- CrossLaps® for Culture (CTX-I) ELISA
- RatTRAP™ (TRAcP 5b) ELISA
- MouseTRAP™ (TRAcP 5b) ELISA
- Rat/Mouse PINP EIA
- Rat-MID™ Osteocalcin EIA
- Serum Pre-Clinical CartiLaps® (CTX-II) ELISA
- Urine Pre-Clinical CartiLaps®(CTX-II) EIA
- Schaller S et al., In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist? Assay Drug Dev Technol. 2005 Oct;3(5):553-80
Sub Disease Areas
Bone Turnover Markers
Cartilage
Corticosterone
Research ConsumablesAnimal Research Products
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| Assays | Certification | Platform | Clinical Area | Portfolio | RUO/IVD |
|---|---|---|---|---|---|
| Alpha CrossLaps® (CTX-I) EIA | 510 (k) exemptCE Marked | Bone TurnoverBone Turnover Markers | Animal ResearchEndocrinology | IVD | |
| Bone Slices | Research Use Only | Research Consumables | Animal Research | RUO | |
| BoneTRAP® (TRAcP 5b) ELISA | CE Marked | Bone TurnoverBone Turnover Markers | Animal ResearchEndocrinology | IVD | |
| Corticosterone EIA | Research Use Only | Corticosterone | Animal Research | RUO | |
| Corticosterone HS (High Sensitivity) EIA | Research Use Only | Corticosterone | Animal Research | RUO | |
| CrossLaps® for Culture (CTX-I) ELISA | Research Use Only | Animal Research | RUO | ||
| Dentine Discs | Research Use Only | Research Consumables | Animal Research | RUO | |
| MouseTRAP™ (TRAcP 5b) ELISA | Research Use Only | Animal Research | RUO |
