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Intact PINP

Product Description

The IDS-iSYS Intact PINP amino-terminal propeptide of type I procollagen assay is intended for the quantitative determination of intact PINP in human serum or plasma on the IDS-iSYS Multi-Discipline Automated System.

  • Detects only trimeric “intact PINP” isoform – which provides an accurate bone formation indicator in renal impaired patients
  • Excellent correlation to existing Intact PINP RIA method – eliminates costly radioactive licensing and waste disposal
  • Combining the Intact PINP with the established IDS-iSYS CTX-I (CrossLaps®) assays from a single sample tube provides an effective tool in the monitoring of osteoporosis treatment and identifying patients at increased risk
  • Correct results independent of kidney function
  • A reference marker for osteoporosis management as indicated by IOF, IFCC and NBHA
  • Accurate results – no overestimation due to increased levels of PINP monomer
  • A complete clinical assay panel supporting bone disease management
    1. Morovat A. et al. IDS iSYS automated intact procollagen-1-Nterminus pro-peptide assay: method evaluation
    2. Koivula M-K. Difference between total and intact assays for N-terminal propeptide of type I procollagen reflects degradation of pN-collagen rather than denaturation of intact propeptide. Ann Clin Biochem 2010; 47: 67–71.
    3. Vasikaran SD et al. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int. 2010; 22(2):391-420.

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Intact PINP


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