Intact PINP
Product Description
The IDS-iSYS Intact PINP amino-terminal propeptide of type I procollagen assay is intended for the quantitative determination of intact PINP in human serum or plasma on the IDS-iSYS Multi-Discipline Automated System.
- Detects only trimeric “intact PINP” isoform – which provides an accurate bone formation indicator in renal impaired patients
- Excellent correlation to existing Intact PINP RIA method – eliminates costly radioactive licensing and waste disposal
- Combining the Intact PINP with the established IDS-iSYS CTX-I (CrossLaps®) assays from a single sample tube provides an effective tool in the monitoring of osteoporosis treatment and identifying patients at increased risk
- Correct results independent of kidney function
- A reference marker for osteoporosis management as indicated by IOF, IFCC and NBHA
- Accurate results – no overestimation due to increased levels of PINP monomer
- A complete clinical assay panel supporting bone disease management
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- Morovat A. et al. IDS iSYS automated intact procollagen-1-Nterminus pro-peptide assay: method evaluation
- Koivula M-K. Difference between total and intact assays for N-terminal propeptide of type I procollagen reflects degradation of pN-collagen rather than denaturation of intact propeptide. Ann Clin Biochem 2010; 47: 67–71.
- Vasikaran SD et al. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int. 2010; 22(2):391-420.
- Product Code: IS-4000 / IS-4030
- Number of Tests: 100
- Sample Type: Serum, SST, plasma (lithium heparin, sodium heparin, ammonium heparin or potassium EDTA)
- Sample Volume: 20 µL (excluding dead volume)
- Assay Range: 2 - 230 ng/mL
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