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BoneTRAP® (TRAcP 5b) ELISA

Product Description

For the quantitative determination of the active isoform 5b of tartrate-resistant acid phosphatase (TRAcP). The BoneTRAP® (TRAcP 5b) ELISA assay is a specific method to detect TRAcP 5b activity freshly liberated from osteoclasts. It is intended for use as an indicator of bone resorption and can be used as an aid in monitoring bone resorption changes in post-menopausal women and individuals diagnosed with osteoporosis undergoing anti-resorptive therapies.

In-vitro, TRAcP 5b activity reflects the number of osteoclasts and therefore the BoneTRAP® (TRAcP 5b) ELISA Assay can be conveniently used to determine osteoclast number in human osteoclast cultures.

  • Derived exclusively from bone-resorbing osteoclasts
  • Low diurnal variation
  • No dietary influence
  • No accumulation into the circulation in renal or hepatic failure
  • 1. Yaziji H, Janckila AJ, Lear SC, et al. 1995 Immunohistochemical detection of tartrate-resistant acid phosphatase in non-hematopoietic human tissues. Am J Clin Pathol 104:397-402.
    2. Lam KW, Li CY, Yam LT, Desnick RJ. 1981 Comparison of the tartrate-resistant acid phosphatase in Gaucher’s disease and leukemic reticuloendotheliosis. Clin Biochem 14:177-181.
    3. Janckila AJ, Neustadt DH, Nakasato YR, et al. 2002 Serum tartrate-resistant acid phosphatase isoforms in rheumatoid arthritis. Clin ChimActa. 320:49-58.
    4. Halleen JM, Alatalo SL, Janckila AJ, et al. 2001 Serum Tartrate-resistant acid phosphatase is a specific and sensitive marker of bone resorption. Clin Chem 47:597-600.
    5. Hannon RA, Clowes JA, Eagleton AC, et al. 2004 Clinical performance of immunoreactive tartrate resistant acid phosphatase isoform 5b as a marker of bone resorption. 34:187-194.

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BoneTRAP® (TRAcP 5b) ELISA

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