Unique Features

  • Detects both N-Midfragment and intact osteocalcin – providing a reproducible test method suitable for monitoring therapeutic treatments of Osteoporosis
  • Extension to the IDS-iSYS Bone Turnover Markers Menu – dual testing of resorption marker (CTX-I) and N-MID® Osteocalcin from a single sample tube improves efficiency
  • Excellent correlation to existing N-MID® Osteocalcin assays – allowing seamless transition between methods
  • Fully automated assay – improving laboratory workflow and throughput
  • Reduced tube handling – wide variety of sample types supported
  • A complete clinical assay panel supporting bone disease management

The IDS-iSYS N-MID® Osteocalcin Assay is intended for the quantitative determination of Osteocalcin in human serum or plasma on the IDS-iSYS Multi-Discipline Automated System.

Results are to be used in conjunction with other clinical and laboratory data to assist the clinician. Osteocalcin is an indicator of osteoblastic activity in human serum and plasma and is intended to be used as an aid in the prevention of osteoporosis.

Osteocalcin, or bone Gla protein (BGP), is the major noncollagenous protein of bone matrix, and consists of 49 amino acids, including three residues of gammacarboxyglutamic acid.Osteocalcin is synthesised in bone by osteoblasts.

Following its production, it is partly incorporated into the bone matrix and partly delivered to the circulatory system.

Osteocalcin is considered to be a marker of bone turnover as opposed to a specific marker of bone formation, as it is released from the bone matrix during the resorption process.

Determination of serum osteocalcin has proved to be valuable as an aid in identifying women at risk of developing osteoporosis, for monitoring bone metabolism during the perimenopause and postmenopause and during antiresorptive therapy.

Hannemann A et al. Reference intervals for serum osteocalcin concentrations in adult men and women from

Schwarz P. et al. Paget’s disease of the bone after treatment with Denosumab: A case report. Bone 50 (2012) 1023–1025.

Vasikaran SD et al. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int. 2010; 22(2):391-420.