Bone Turnover Markers

Bone Turnover Markers for use in Translational Research

Immunodiagnostic Systems Limited (referred to hereafter as IDS) offers a full panel of bone turnover markers (BTM’s) for translational research, including both bone resorption [C-terminal telopeptides (CTX-I)], osteoclast markers [tartrate-resistant-acid phosphatase 5b (TRAcP5b)], and bone formation markers [Procollagen type 1 propeptides (PINP)] and Osteocalcin suitable for use with cell culture and animal models.

IDS are committed to provide highly accurate and reproducible assays for the measurement of bone turnover markers, thus ensuring reliability of results. Throughout life, old bone is constantly removed (resorption) and replaced by new bone (formation). This continual process is essential for the maintenance of healthy bone mass and micro-architecture.  When addressing changes in bone turnover at the organ or organism level, monitoring tools adequately reflecting the outcome of tissue homeostasis become particularly critical. In this context, bioassays targeting the quantification of various degradation and formation products of bone matrix elements represent a useful approach¹.