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InaKtif MGP (dp-ucMGP)

Product Description

An automated assay for the quantitative determination of the inactive dephosphorylated-uncarboxylated (dp-uc) isoform of Matrix Gla-Protein (MGP) in human plasma on the IDS-iSYS Multi-Discipline Automated System. Measurement of dp-ucMGP are used in the assessment of vitamin K status in the arterial vessel wall.

  • Utilise conformation-specific monoclonal antibodies to ensure accurate dp-ucMGP circulating levels
  • Correlated to the widely published lab-develop dp-ucMGP ELISA assay method
  • Wide assay range suitable for Chronic Kidney Disease, Haemodialysis and Vitamin K Antagonist treated patients
  • First fully automated CE marked IVD dp-ucMGP test for achieving fast and highly reproducible results for diagnostic and follow up of patients
    1. Price PA, Urist MR, Otawara Y: Matrix Gla protein, a new gammacarboxyglutamic acid-containing protein which is associated with the organic matrix of bone. Biochem Biophys Res Commun 1983, 117:765–771.
    2. Cranenburg EC, Koos R, Schurgers LJ, Magdeleyns EJ, Schoonbrood TH, Landewé RB et al. Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemost. 2010; 104: 811–822.
    3. Schurgers LJ, Spronk HM, Skepper JN, Hackeng TM, Shanahan CM, Vermeer C et al. Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. J Thromb Haemost. 2007; 5: 2503–2511.
    4. Murshed M, Schinke T, McKee MD et al. Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol 2004; 165:625-630.
    5. Schurgers LJ, Cranenburg EC, Vermeer C. Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thromb Haemost. 2008; 100: 593–603.

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InaKtif MGP (dp-ucMGP)


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