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Rubella IgG

Product Description

The Rubella IgG test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers, for quantitative determination of specific IgG class antibodies directed against the Rubella virus in samples of human serum or plasma (K3-EDTA, Sodium Citrate).

This assay is used as a diagnostic aid when assessing immunity status of patients related to Rubella virus infection.

  • Complete panel for the diagnosis of Rubella with IgG, IgM and IgG Avidity testing
  • Significant sensitivity in the primary infection for both IgG and IgM tests
  • The Avidity assay can be run in early stage of acute infections due to the high sensitivity of the IgG tests.
    1. DM Horstmann. Rubella in : Evans A.S., ed. Viral infections of humans : epidemiology and control. New York: Plenum Press,1976; 409-427.
    2. Askin DF. Intrauterine infections. Neonatal.Netw. 2004; 23(5):23-30.
    3. Cooper LZ,Alford Jr.CA. Rubella. In : Remington JS, Klein JO, editors. Infectious Diseases of the Fetus and Newborn infant. Philadelphia,PA : Elsevier Saunders ; 2006 : 893-926.
    4. Atreya CD, Mohan KV, Kulkami S. Rubella virus and birth defects : molecular insights into the viral teratogenesis at the cellular level. A. Clin. Mol. Terato. 2004; 70 (7): 431-7.
    5. Department of Vaccines and Biologicals, WHO. Report of a meeting on preventing congenital Rubella syndrome : immunization strategies, surveillance needs. Geneva : World Health Organization,2000.
    6. Best JM, Banatvala JE. Rubella. In . AJ Zuckerman, JE Banatvala, JR Pattison,eds. Principles and practice of clinical virology. 4th Chichester : John Wiley,2000: 387-418.
    7. Best JM, O’Shea S, Tipples G,Davies N, Al-Khusaiby SM, Krause A, Hesketh LM, Jin L, Enders G. Interpretation of Rubella serology in pregnancy-pitfalls and problems. BMJ. 2002;325 (7356): 147-148
    8. Banatvala JE and Brown DWG. 2004. Rubella. Lancet 363 : 1127-1139
    9. Banatvala JE,Best JM, O’Shea S,Dudgeon JA. Persistence of Rubella antibodies following vaccination : detection of viremia following experimental challenge. Rev. Infect. Dis 1985; 7(suppl 1): S86-90
    10. Thomas HIJ, Morgan-Capner P, Roberts A, Hesketh L. Persistent Rubella-specific IgM reactivity in the absence of recent primary Rubella and Rubella reinfection. J. Med. Virol. 1992;36 :188-92.
    11. O. White and F.J. Fenner. 1994. Medical Virology 4th ed. Academic Press, San Diego,CA.
    12. Hamkar, S. Jalivand, T. Mokhtari-Azad, K. Nouri Jelyani, H. Dahi-Far,H. Soleimanjahi and R. Nategh.2005. Assessment of IgM enzyme immunoassay and IgG avidity assay for distinguish between primary and secondary immune response to Rubella vaccine. J. Virol. Methods 130 : 59-65.
    13. Hoffman and U.G. Liebert. 2005. Significance of avidity and immunoblot analysis for Rubella IgM-positive serum samples in pregnant women. J. Virol. Methods 130: 66-71.
    14. Herne, K. Hedman and P. Reedik. 1997. Immunoglobulin avidity in the serodiagnosis of congenital Rubella syndrome. Eur. J. Clin. Microbiol. Infect. Dis. 16 : 763-766.

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Rubella IgG


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