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Rubella IgG Avidity

Product Description

The Rubella IgG Avidity test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers, for determination of Avidity Index of specific IgG class antibodies directed against Rubella virus in samples of human serum or plasma (K3-EDTA, Sodium Citrate). The possibility of differentiating antibodies at high avidity from low avidity allows to supply interesting clinical information.

This assay is used as a diagnostic aid when assessing immunity status of patients related to Rubella virus infection.

  • Complete panel for the diagnosis of Rubella with IgG, IgM and IgG Avidity testing
  • The Avidity assay can be run in early stage of acute infections due to the high sensitivity of the IgG tests.
    1. DM Horstmann. Rubella in : Evans A.S., ed. Viral infections of humans : epidemiology and control. New York: Plenum Press,1976; 409-427.
    2. Askin DF. Intrauterine infections. Neonatal.Netw. 2004; 23(5):23-30.
    3. Cooper LZ,Alford Jr.CA. Rubella. In : Remington JS, Klein JO, editors. Infectious Diseases of the Fetus and Newborn infant. Philadelphia,PA : Elsevier Saunders ; 2006 : 893-926.
    4. Atreya CD, Mohan KV, Kulkami S. Rubella virus and birth defects : molecular insights into the viral teratogenesis at the cellular level. A. Clin. Mol. Terato. 2004; 70 (7): 431-7.
    5. Department of Vaccines and Biologicals, WHO. Report of a meeting on preventing congenital Rubella syndrome : immunization strategies, surveillance needs. Geneva : World Health Organization,2000.
    6. Best JM, Banatvala JE. Rubella. In . AJ Zuckerman, JE Banatvala, JR Pattison,eds. Principles and practice of clinical virology. 4th Chichester : John Wiley,2000: 387-418.
    7. Best JM, O’Shea S, Tipples G,Davies N, Al-Khusaiby SM, Krause A, Hesketh LM, Jin L, Enders G. Interpretation of Rubella serology in pregnancy-pitfalls and problems. BMJ. 2002;325 (7356): 147-148
    8. Banatvala JE and Brown DWG. 2004. Rubella. Lancet 363 : 1127-1139
    9. Banatvala JE,Best JM, O’Shea S,Dudgeon JA. Persistence of Rubella antibodies following vaccination : detection of viremia following experimental challenge. Rev. Infect. Dis 1985; 7(suppl 1): S86-90
    10. Thomas HIJ, Morgan-Capner P, Roberts A, Hesketh L. Persistent Rubella-specific IgM reactivity in the absence of recent primary Rubella and Rubella reinfection. J. Med. Virol. 1992;36 :188-92.
    11. O. White and F.J. Fenner. 1994. Medical Virology 4th ed. Academic Press, San Diego,CA.
    12. Hamkar, S. Jalivand, T. Mokhtari-Azad, K. Nouri Jelyani, H. Dahi-Far,H. Soleimanjahi and R. Nategh.2005. Assessment of IgM enzyme immunoassay and IgG avidity assay for distinguish between primary and secondary immune response to Rubella vaccine. J. Virol. Methods 130 : 59-65.
    13. Hoffman and U.G. Liebert. 2005. Significance of avidity and immunoblot analysis for Rubella IgM-positive serum samples in pregnant women. J. Virol. Methods 130: 66-71.
    14. Herne, K. Hedman and P. Reedik. 1997. Immunoglobulin avidity in the serodiagnosis of congenital Rubella syndrome. Eur. J. Clin. Microbiol. Infect. Dis. 16 : 763-766.

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Rubella IgG Avidity


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