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TOXO IgG Avidity

Product Description

The Toxo IgG Avidity test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers, for determination of Avidity Index of specific IgG class antibodies directed against the Toxoplasma gondii (Toxo) in samples of human serum or plasma (K3-EDTA, Sodium Citrate).

The possibility of differentiating antibodies at high avidity from low avidity allows to supply interesting clinical information. This assay is used as a diagnostic aid when assessing immunity status of patients related to Toxoplasmosis.

  • Complete panel for identification of the infection to Toxoplasmosis.
  • Significant sensitivity of the IgG test allows to evaluate the seroconversion follow-up.
  • The Avidity assay can be run in the early stage of acute infection due to the high sensitivity of the IgG test
    1. Ryan KJ; Ray CG ( editors ) ( 2004 ). Sherris Medical Microbiology ( 4th ). McGraw Hill. pp 723-7. ISBN 0838585299.
    2. Jones JL et al. Congenital Toxoplasmosis : A Review. CME Review Article Vol. 56, Number 5 2001 ; 296-305.
    3. Torda A ( 2001 ). “ Toxoplasmosis. Are cats really the source ? “. Aust Fam Physician 30 (8): 743-7. PMID 11681144
    4. Jones JL, Kruszon-Moran D, Wilson M, McQuillan G, Navin T, McAuley JB : Toxoplasma gondii infection in the United States : seroprevalence and risk factors. Am J Epidemiol 2001; 154; ( 4 ); 357-65.
    5. Guerina NG, Hsu HW, Meissner HC, Maguire JH, Lynfield R, Stechenberg B, et al. : Neonatal serologic screening and early treatment for congenital Toxoplasma gondii The New England Regional Toxoplasma Working Group. N Engl J Med 1994;330,(26 ); 1858-63.
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    7. Montoya JG : Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. J Infect Dis 2002; 185 Suppl 1; S73-82.
    8. Remington JS, McLeod R, Thulliez P, Desmonts G ( 2001 ) Toxoplasmosis, p. 205-346. In J.S. Remington and Klein ( ed. ), Infectious diseases of the fetus and newborn infant,5th W.B. Saunders, Philadelphia,Pa.
    9. Thulliez P, Daffos F, Forestier f : Diagnosis of Toxoplasma infection in pregnant woman and the unborn child : current problems. Scand J Infect Dis Suppl 1992;84; ( 18-22).
    10. Montoya JG, Remington JS. Toxoplasma gondii. In : Mandel GL, Bennett JE, Dolin R, eds,Mandell, Douglas and Bennett ‘ Principles and Practice of Infectious Diseases,5thg Ed. Philadelphia : Churchill Livingstone,2000, pp 2858-2888.
    11. Wilson M, McAuley JM. Toxoplasma. In : Murray PR, Baron ES, Pfaller MA et al., eds. Manual of Clinical Microbiology, 7th Washington,DC : ASM Press,1999, pp 1374-1382.
    12. Hedman K, Lappalainen M, Seppaia I, Makela O: Recent primary toxoplasma infection indicated by a low avidity of specific IgG. J. Infect Dis 1989; 159, ( 4 ); 736-40.
    13. Montoya JG, Remington JS. Studies on the serodiagnosis of toxoplasmic lymphadenitis. Clin Infect Dis 1995; 20; ( 4 ) ; 781-9.
    14. Jenun PA, Stray-Pedersen B, Gundersen AG: Improved diagnosis of primary Toxoplasma gondii infection in early pregnancy by determination of anti-toxoplasma immunoglobulin G avidity. J Clin Microbiol 1997; 35; ( 8 ) 1972-7.

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