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RatLaps® (CTX-I) EIA

Product Description

For determination of bone related degradation products from C-terminal telopeptides of type I collagen in rat/mouse serum and rat urine.

  • Assessments of bone resorption in rodents1-3
  • Ovariectomised (OVX) rats and mice
  • Thyroidparathyroidectomised (TPTX) rats
  • Rat and mouse models of bone metastases
  • Knock-out and transgenic mice with effect in bone resorption
  • Allows assessment of Bone Resorption in Tissue Culture, Calvariae, tibiae, or metatarsals from rats and mice
  • Part of a complete assay panel supporting bone research
    1. Mackenzie NC et al., Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice. PLoS One. 2012;7(2):e32177
    2. Pennisi P et al., L-arginine supplementation normalizes bone turnover and preserves bone mass in streptozotocin-induced diabetic rats. J Endocrinol Invest. 2009 Jun;32(6):546-51.
    3. Schaller S et al., In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist? Assay Drug Dev Technol. 2005 Oct;3(5):553-80.
    4. Bjarnason NH & Christiansen C. Early Response in Biochemical Markers Predicts Long-term Response in Bone Mass During Hormone Replacement Therapy in Early Postmenopausal Women. Elsevier 26; 561-569 (2000).
    5. Bonde M, Garnero P, Fledelius C, et al. Measurement of bone degradation products in serum using antibodies reactive with an isomerized from of an 8 amino acid sequence of the C-telopeptide of Type I collagen. J Bone Miner Res 12:1028-1034 (1997).
    6. Bonde M, Qvist P, Fledelius C, et al. Applications of an enzyme immunoassay for a new marker of bone resorption (CrossLaps®) -follow up on hormone replacement therapy and osteoporosis risk assessment. J Clin Endocrinol & Metab 80:864-8 (1995).

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RatLaps® (CTX-I) EIA


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