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Endocrine Hypertension

A Simple and Accurate Solution for the Assessment of Endocrine Hypertension.

30% of the adult population suffer from hypertension and in 15-20% of these patients it may be due to endocrine causes, such as Primary Aldosteronism (PA).  In another 5% of patients the elevated blood pressure is due to Renovascular Hypertension. 1 – 3 

In PA excess, aldosterone levels may be produced due to an adenoma (Conn’s syndrome) or hyperplasia. Patients with this condition are at a stronger risk of heart disease and stroke than those with essential hypertension. 4 PA patients also have higher cardiovascular morbidity and mortality than age and sex-matched patients with essential hypertension. 

Clinical guidelines recommended Aldosterone to Renin ratio (ARR) as a simple and effective screening test for the presence of PA.5 Renin itself can also be used to stratify risk in essential hypertension patients.

The ARR can be determined from a single plasma sample tube, to facilitate laboratory workflow efficiency:

  • Fully automated chemiluminescent assays offer a convenient reagent handling with on-board storage of the reagents. 
  • Demonstrated clinical application with validated Aldo Renin Ratio (ARR) and suppression test cut-offs.6
  1. Kearney, PM et al. Lancet, 365 (9455): 217-223, 2005.
  2. Rossi, GP et al. Crit Rev Clin Lab Sci, 44: 1-85, 2007.
  3. Mulatero, P. et al. J Clin Endocrinol Metab, 89(3): 1045–1050, 2004.
  4. Milliez, P. et al. J Am Coll Cardiol, 45 (8): 1243-8, 2005.
  5. Funder, J.W. et al. J Clin Endocrinol Metab 93 (9): 3266-81, 2008.
  6. Bidlingmaier, M. et al. J Clin Endocrinol Metab, 107(5): e2027–e2036,2022.

Endocrine Hypertension Products

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IDS-iSYS Aldosterone CE MarkedFDA Cleared i10iSYS Endocrine Hypertension Endocrinology IVD
IDS-iSYS Direct Renin CE MarkedFDA Cleared i10iSYS Endocrine Hypertension Endocrinology IVD

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