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IDS-iSYS Direct Renin

Product Description

The IDS-iSYS Renin assay is intended for the quantitative determination of Direct Renin in human EDTA plasma on IDS Systems.

Results are to be used in conjunction with other clinical and laboratory data to assist the clinician in the assessment of hypertension related syndromes.

  • Highly specific monoclonal antibodies directed to the active renin enzyme site
  • Low cross-reactivity to Prorenin (<2.8%)
  • Referenced to the IS WHO 68/356
  • Time to first result is 43 minutes
  • Accurate and reliable patient results standardisation with the WHO IRP 68/356
  • Demonstrated clinical application with validated cut-off for the Aldosterone to Renin Ratio
  • Cost effective, process standardisation, long-term consistency
  • Publications using the IDS-iSYS Direct Renin assay

    1. Genovesi S, Antolini L, Orlando A, Tassistro E, Giussani M, Nava E, Turolo L, Manolopoulou J, Parati G, Morganti A. Aldosterone-to-renin ratio depends on age and sex in children attending a clinic for cardiovascular risk assessment. J Hypertens. 2018 Feb;36(2):344-352.
    2. O’Shea PM, Griffin TP, Browne GA, Gallagher N, Brady JJ, Dennedy MC, Bell M, Wall D, Fitzgibbon M. Screening for primary aldosteronism using the newly developed IDS-iSYS® automated assay system. Pract Lab Med. 2016 Nov 13;7:6-14.
    3. O’Shea P, Brady JJ, Gallagher N, Dennedy MC, Fitzgibbon M. Establishment of reference intervals for aldosterone and renin in a Caucasian population using the newly developed Immunodiagnostic Systems specialty immunoassay automated system. Ann Clin Biochem. 2016 May;53(Pt 3):390-8.
    4. Manolopoulou J, Fischer E, Dietz A, Diederich S, Holmes D, Junnila R. Clinical validation for the aldosterone-to-renin ratio and aldosterone suppression testing using simultaneous fully automated chemiluminescence immunoassays. J. Hypertens. 2015;33:2500–2511.

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IDS-iSYS Direct Renin

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