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IDS-iSYS Aldosterone

Product Description

The IDS-iSYS Aldosterone assay is intended for the quantitative determination of Aldosterone in human EDTA plasma on IDS Systems.

Results are to be used in conjunction with other clinical and laboratory data to assist in the clinical assessment of hypertension related syndromes.

  • Calibrated using gold standard Isotope Dilution Mass Spectrometry from the RfB
  • Highly specific monoclonal antibody
  • No cross-reaction to spironolactone and fludrocortisone up to levels of 0.3mg/mL (<0.001%)
  • Time to first result is 43 minutes
  • No radioactive, hazardous waste
  • Reliable patient results due to calibration standardised to IDMS
  • Demonstrated clinical application with validated Aldo Renin Ratio (ARR) and suppression test cut-offs
  • Cost effective, process standardisation, long-term consistency
    1. Genovesi S, Antolini L, Orlando A, Tassistro E, Giussani M, Nava E, Turolo L, Manolopoulou J, Parati G, Morganti A. Aldosterone-to-renin ratio depends on age and sex in children attending a clinic for cardiovascular risk assessment. J Hypertens. 2018 Feb;36(2):344-352.
    2. O’Shea PM, Griffin TP, Browne GA, Gallagher N, Brady JJ, Dennedy MC, Bell M, Wall D, Fitzgibbon M. Screening for primary aldosteronism using the newly developed IDS-iSYS® automated assay system. Pract Lab Med. 2016 Nov 13;7:6-14.
    3. O’Shea P, Brady JJ, Gallagher N, Dennedy MC, Fitzgibbon M. Establishment of reference intervals for aldosterone and renin in a Caucasian population using the newly developed Immunodiagnostic Systems specialty immunoassay automated system. Ann Clin Biochem. 2016 May;53(Pt 3):390-8.
    4. Manolopoulou J, Fischer E, Dietz A, Diederich S, Holmes D, Junnila R. Clinical validation for the aldosterone-to-renin ratio and aldosterone suppression testing using simultaneous fully automated chemiluminescence immunoassays. J. Hypertens. 2015;33:2500–2511.
    5. Fortunato A, Prontera C, Masotti S, Franzini M, Marchetti C, Giovannini S, Zucchelli GC, Emdin M, Passino C, Clerico A. State of the art of aldosterone immunoassays. A multicenter collaborative study on the behalf of the Cardiovascular Biomarkers Study Group of the Italian Section of European Society of Ligand Assay (ELAS) and Società Italiana di Biochimica Clinica (SIBIOC). Clin Chim Acta. 2015 Apr 15;444:106-12.

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IDS-iSYS Aldosterone


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