Urine CartiLaps® (CTX-II) EIA
Product Description
For the determination of degradation products of C-terminal telopeptides of Type II collagen in human urine.
- Quantitative assessment of disease activity (structural damage of articular cartilage) in patients with RA and OA
- Prognosis of disease activity in patients with RA and OA
- Early assessment of long-term effect of therapy in patients with RA
- Excellent correlation to immunohistochemistry and imaging techniques
- Part of a complete assay panel supporting clinical bone and cartilage research
Results are to be used in conjunction with other clinical and laboratory data for the indication of degradation of cartilage and may be used as an aid for:
- quantitative assessment of disease activity (structural damage of articular cartilage) in patients with RA and OA
- prognosis of disease activity in patients with RA and OA, and
- early assessment of long-term effect of therapy in patients with RA
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- Ceunick F De. et al., Urinary collagen type II C-telopeptide fragments are sensitive markers of matrix metalloproteinase dependent cartilage degradation in rat adjuvant induced arthritis. J Rheumatol (2003); 30: 1561-1564.
- Christgau S. et al., Suppression of Elevated Cartilage Turnover in Postmenopausal Women and in Ovariectomized Rats by Estrogen and a Selective Estrogen-Receptor Modulator (SERM). Menopause (2004); 11: 508-518.
- Christgau S. et al., Cartilage Degradation In Glucosamine Sulphate Treated Knee Osteoarthritis Patients With Elevated Levels Of Urinary Collagen Type II C-Telopeptide Fragments. Clin Exp Rheumatol. (2004) 22(1):36-42.
- ChristgauS. et al., Collagen type II degradation products in urine as an index of cartilage degradation. Bone (2001); 29: 209-215.
- Forsblad d’Elia H. et al., Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial. Arthritis Res Ther (2004); 6: R457-68.
- Garnero P. et al., Association of 10 molecular markers of bone, cartilage and synovium with disease activity and joint damage in hip osteoarthritis patients: the ECHODIAH cohort. ACR 2003.
- Product Code: AC-10F1
- Number of Tests: 96 wells
- Sample Type: Urine
- Sample Volume: 40 µL
- Assay Range: 0-10 ng/mL
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Related Products
| Assays | Certification | Platform | Clinical Area | Portfolio | RUO/IVD |
|---|---|---|---|---|---|
| Human COMP ELISA | CE Marked | Cartilage Markers | Endocrinology | IVD | |
| Serum Pre-Clinical CartiLaps® (CTX-II) EIA | Research Use Only | Cartilage | Animal Research | RUO |