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Scl-70

Product Description

The Scl-70 test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers.  It is used for the quantitative determination of the specific IgG antibodies directed against the Scl-70 (DNA topoisomerase I) antigen in human samples of serum or plasma (EDTA).

    1. CA von Mühlen, EM Tan. Autoantibodies in the diagnosis of systemic rheumatic diseases. Sem Arthr Rheum 1995; 24: 323-58.
    2. RL Humbel. Auto-immunité, auto-anticorps et maladie. In : Humbel RL, ed. Autoanticorps et maladies autoimmunes, Paris, France : Edition Scientifiques Elsevier; 1997: 17-20.
    3. PN Hollingsworth, SC Pummer, RL Dawkins. Antinuclear antibodies. In : Peter JB, Shoenfeld Y, eds. Autoantibodies. Amsterdam, The Netherlands : Elsevier Science BV; 1996: 74-90.
    4. CA Slater, RB Davis, RH Shmerling. Antinuclear antibodies testing. A study of clinical utility. Arch Int Med 1996; 156: 1421-5.
    5. RL Humbel. Detection of antinuclear antibodies by immunofluorescence. In : van Venrooij, Maini RN eds. Manual of Biological Markers of Disease. Dordrecht, The Netherlands : Kluwer; 1993: A2:1-16.
    6. National Committee for Clinical Laboratory Standardization. Quality assurance for the indirect immunofluorescence test for autoantibodies to nuclear antigen ( IF-ANA ). Approved Guideline. Wayne, PA: NCCLS I/LA2-A, vol. 16 ( 11 ); 1996.
    7. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis ( scleroderma ). Arthritis Rheum 1980; 23 : 581-90.
    8. HJ Lakomek, HH Guldner, FA Bautz, G Goerz, P Kind, M Mensing, et al. Nuclear antibodies as serologic markers in progressive systemic scleroderma. Hautarzt 1987; 38: 63-9
    9. CC Bunn, CP Denton, X Shi-Wen, C Knight, CM Black. Anti-RNA polymerases and other autoantibody specificities in systemic sclerosis. Br J Rheumatol 1998; 37: 15-20.
    10. D Vazquez-Abad, NF Autoantibodies in systemic sclerosis. Int Rev Immunol 1995; 12: 145-57.
    11. EC Le Roy, T Krieg, C Black, TA Jr Medsger, R Fleischmajer, N Rowell, et al. Scleroderma ( Systemic Sclerosis ) : classification, subsets and pathogenesis. J Rheumatol 1988; 15 : 202-5.
    12. RL Humbel. Auto-immunité, auto-anticorps et maladie auto-immunes. In : Humbel RL, ed. Autoanticorps et maladies autoimmunes, Paris: Elsevier 1997. pp. 71-3.
    13. P D’Arpa, PS Machlin, H Ratie, NF Rothfield, DW Cleveland, WC Earnshaw. cDNA cloning of human topoisomerase I. Catalytic activity of a 67.7 kDa carboxyl-terminal fragment. Proc Natl Acad Sci USA; 85: 2543-7.
    14.  P D’Arpa, H White-Cooper, DW Cleveland, NF Rothfield, WC Earnshaw. Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I ( Scl-70 ) recognized by sera of scleroderma patients. Arthritis Rheum 1990; 33: 1501-11.
    15. C Bona, N Rothfield. Autoantibodies in scleroderma and tightskin mice. Curr Opin immunol 1994; 6: 931-7.
    16. D Vazquez-Abad,CA Russell, SM Cusick, WC Earnshaw, NF Longitudinal study of anticentromere and antitopoisomerase I isotypes. Clin Immunol Immunopathol 1995; 74: 257-70.
    17. GC Fanning, KI Welsh, C Bunn, A Du Bois, CM Block. HLA association in three mutually exclusive autoantibody subgroups in UK systemic sclerosis patients. Br J Rheumatl 1998; 37: 201-7.
    18. D Basu, JD Reveille. Anti-Scl-70. Autoimmunity 2005; 38: 65-72.
  • Product Code: IS-AI1108
  • Number of Tests: 50
  • Sample Type: Human Serum or Plasma (EDTA)
  • Sample Volume: 4 µL
  • Assay Range: 0-640 AU/mL
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