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Centromere B

Product Description

The Centromere B test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers. It is used for the quantitative determination of the specific IgG antibodies directed against the Centromere B antigen in human samples of serum or plasma (EDTA).

    1. CA von Mühlen, EM Tan. Autoantibodies in the diagnosis of systemic rheumatic diseases. Sem Arthr Rheum 1995; 24: 323-58.
    2. RL Humbel. Auto-immunité, auto-anticorps et maladie. In : Humbel RL, ed. Autoanticorps et maladies autoimmunes, Paris, France : Edition Scientifiques Elsevier; 1997: 17-20.
    3. PN Hollingsworth, SC Pummer, RL Dawkins. Antinuclear antibodies. In : Peter JB, Shoenfeld Y, eds. Autoantibodies. Amsterdam, The Netherlands : Elsevier Science BV; 1996: 74-90.
    4. CA Slater, RB Davis, RH Shmerling. Antinuclear antibodies testing. A study of clinical utility. Arch Int Med 1996; 156: 1421-5.
    5. RL Humbel. Detection of antinuclear antibodies by immunofluorescence. In : van Venrooij, Maini RN eds. Manual of Biological Markers of Disease. Dordrecht, The Netherlands : Kluwer; 1993: A2:1-16.
    6. National Committee for Clinical Laboratory Standardization. Quality assurance for the indirect immunofluorescence test for autoantibodies to nuclear antigen ( IF-ANA ). Approved Guideline. Wayne, PA: NCCLS I/LA2-A, vol. 16 ( 11 ); 1996.
    7. A Servettaz, M Tamby, P Guilpain, J Reinbolt, Y Allanore, A Kahan, et al. Anti-endothelian cell antibodies from patients with limited cutaneous systemic sclerosis bind to centromeric protein B ( CENP-B ). Clin Immunol 2006; 120: 212-9.
    8. KT Ho, JD Reveille. The clinical relevance of autoantibodies in scleroderma. Arthritis Res Ther 2003; 5: 80-93.
    9. E Hachulla, S Dubucquoi. Intéret des anticorps antinucléaires pour le diagnostic, la classification et le prognostic de la sclérodermie systémique.Rev Méd Interne 2004; 25: 442-7.
    10. M Harris, A Rosen. Autoimmunity in scleroderma: the origin, pathogenetic role, and clinical significance of autoantibodies. Curr Opin Rheumatol 2003; 15: 778-804.
    11. P Nietert, H Mitchell, M Bolster, S Shaftman, B Tilley, RM Silver. Racial variation in clinical and immunological manifestation of systemic sclerosis. J Rheumatol 2006; 33: 263-8.
    12. S Miyawaki, H Asanuma, S Nishiyama, Y Yoshinaga. Clinical and serological heterogeneity in patients with anticentromere antibodies. J Rheumatol 2005; 32: 1488-94.
  • Product Code: IS-AI1110
  • Number of Tests: 50
  • Sample Type: Human Serum or Plasma (EDTA)
  • Sample Volume: 4 µL
  • Assay Range: 0-640 AU/mL
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