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LKM-1

Product Description

The LKM-1 (Liver Kidney Microsomes type 1) test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers. It is used for the quantitative determination of specific IgG class antibodies directed against Liver Kidney Microsomes type 1, in human samples of serum or plasma (EDTA and Sodium Citrate).

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    3. Ngu JH et al. Population-based epidemiology study of autoimmune disease: a disease of older women? J Gastroenterol Hepatol, 2010. 25(10): 1681-6.
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    6. Rizzetto M, Swana G, Doniach D. Microsomal antibodies in active chronic hepatitis and other disorders. Clin Exp Immunol 1973; 15: 331-44.
    7. Gueguen M, Meunier-Rotival M, Bernard O, Alvarez F. Anti-liver kidney microsome antibody recognizes a cytochrome P450 from IID subfamily. J Exp Med 1988; 168: 801-6.
    8. Philipp T, Durazzo M, Trautwein C, Alex B, Straub P, Lamb JG, et al. Recognition of uridine diphosphate glucoronisyl transferases by LKM-3 antibodies in chronic hepatitis D. Lancet 1994; 344:578-81.
    9. Lenzi M, Ballardini G, Fusconi M, Cassani F, Selleri L, Volta U, et al. Type 2 autoimmune hepatitis and hepatitis C virus infection. Lancet 1990; 335:258-9.
    10. Declos-Valee JC, Hajaoui O, Yamamoto AM, Jacqz-Aigrin E and Alvarez F. Conformational epitopes on CYP2D6 are recognized by Liver/kidney microsomal antibodies. Gastroenterology 108: 467-470.1995.
    11. Dalekos GN, Wedemeyer H, Obermayer-Straub P, Kayser A, Barut A, Frank H and Manns MP. Epitope mapping of cytochrome P450 2D6 autoantigen in patients with chronic hepatitis C during alpha-interferon treatment. J. Hepatol. 30(3): 366-375.1999.
    12. Miyakawa H, Kikazawa E, Abe K, Kikuchi K, Fujikawa H, Matsushita M, Kawaguchi N, Morizane T, Ohya K, Kako M. Detection of anti-LKM-1 (anti-CYP2D6) by enzyme-linked immunosorbent assay in adult patients with chronic liver diseases. Autoimmunity, 1999;30(2):107-14
    13. Kekar N, Ma Y, Davies ET, Cheeseman P, Mieli-Vergani G, Vergani D. Detection of liver kidney microsomal type 1 antibody using molecularly based immunoassay. Journal of Clinical Pathology 2002;55(12): 906-909.
  • Product Code: IS-AI1802
  • Number of Tests: 50
  • Sample Type: Human Serum or Plasma (EDTA and Na-Citrate)
  • Sample Volume: 10 µL
  • Assay Range: 0 -300 AU/mL
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