i-Tracker anti-Rituximab
Product Description
i-Tracker anti-Rituximab is an automated assay intended for the quantitative measurement of Anti Rituximab antibodies (anti-drug antibodies: ADAb) in human serum or plasma samples.
- Innovative CLIA technology
- Quantitative measurement of drug and anti-drug antibodies
- First results in less than 35 minutes; 60 results/hour
- Validated on princeps and biosimilars
- Controls and calibrators included
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- Mark S. Cragg & al. A new anti-idiotype antibody capable of binding rituximab on the surface of lymphoma cells. Blood. 2004;104:2540-2542.
- Magda Nakou & al. Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response. Arthritis Research & Therapy 2009, 11:R131.
- Saito K & al. Extremely high titer of anti-human chimeric antibody following re-treatment with rituximab in a patient with active systemic lupus erythematosus. Rheumatology (Oxford). 2005 Nov;44(11):1462-4. Epub 2005 Aug 16.
- Rozman S, & al. Population pharmacokinetics of rituximab in patients with diffuse large B‐cell lymphoma and association with clinical outcome. Br J Clin Pharmacol. 2017 Aug; 83(8): 1782–1790.
- Tout M, & al. Rituximab exposure is influenced by baseline metabolic tumor volume and predicts outcome of DLBCL patients: a Lymphoma Study Association report. Blood. 2017 May 11;129(19):2616-2623.
- Sawalha Y, & al. Is rituximab sub-optimally dosed in indolent B cell lymphoma? Br J Haematol. 2016 Sep;174(5):721-9.
- Product Code: CTR 003-50
- Number of Tests: 50
- Sample Type: Serum or plasma
- Sample Volume: 100 µL
- Assay Range: 10 - 2000 ng/mL
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