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CMV IgG Avidity

Product Description

The CMV IgG test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers, for quantitative determination of specific IgG class antibodies directed against Cytomegalovirus virus in samples of human serum or plasma (K3-EDTA, Sodium Citrate).

This assay is used as a diagnostic aid when assessing immunity status of patients related to CMV (Cytomegalovirus) infection.

  • Complete panel for the diagnosis of the CMV infection, including CMV IgG, IgM and IgG Avidity
  • Significant sensitivity in the primary infection for both IgG and IgM tests
  • The high specificity of the IgM test allows the observation of the decreasing IgM concentration three months after the onset of the infection
  • The IgM titer decrease is correlated to the increasing value of the IgG avidity index
    1. Koichi Y,Arvin AM, G. Campadelli-Fiume, Mocarski E, Moore P, Roizman B, Whitley R (2007). Human herpesviruses : biology,therapy and immunoprophylaxis. Cambridge,UK : Cambridge University Press. ISBN 0-521-82714-0
    2. Ryan KJ, Ray CG ( editors ) ( 2004 ). Sherris Medical Microbiology ( 4th ). McGraw Hill. Pp. 556;566-9. ISBN 0-8385-8529-9.
    3. Hummel M, Abecassis MM. A model for reactivation of CMV from latency. J. Clin. Virol. 2002; 25 Suppl 2 : S123-36.
    4. Dowd JB, Aiello AE, Alley DE ( 2009 ). Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III. Epidemiol. Infect. , 137: 58-65.
    5. Sweet C. The pathogenicity of Cytomegalovirus. FEMS Microbiol. Rev.,23 : 457-482
    6. Azam AZ, Vial Y, Fawer CL,Zufferey J, Hohlfeld P. Prenatal diagnosis of congenital cytomegalovirus infection. Obstet. And Gynec., 97:443-448,2001.
    7. Stagno S, Pass RF, Cloud G et al. Primary Cytomegalovirus infection in pregnancy. Incidence, transmission to fetus and clinical outcome. J. Amer. Med. Ass., 256: 1904-1908,1986.
    8. Lazzarotto T,Gabrielli L, Lanari M, Guerra B, Bellucci T, Sassi M, Landini MP. Congenital cytomegalovirus infection: recent advances in the diagnosis of maternal infection. Hum. Immunol. 2004 May; 65(5) : 410-415.
    9. Van De Meer JTM, Drew WL, Bowden RA et al. Summary of the international consensus symposium on advances in the diagnosis, treatment and prophylaxis of cytomegalovirus infection. Antivir. Res., 32: 119-140,1996.
    10. Lazzarotto T, Spezzacatena P, Pradelli P. et al. Avidity of immunoglobulin G directed again human cytomegalovirus during primary and secondary infections in immunocompetent and immnucompromised patients. Clin. Diagn. Lab. Immunol., 4: 469-473, 1997.
    11. Söderberg-Nauclé C, Fish KN, Nelson JA. Reactivation of latent human cytomegalovirus by allogenic stimulation of blood cells from healthy donors. Cell 1997; 91:119.
    12. Ross SA, Arora N, Novak Z, et al. Cytomegalovirus reinfections in healthy seroimmune women. J Infect Dis 2010; 201:386.
    13. Deyi YM, Goubau P, Bodéus M. False positive IgM antibody tests for cytomegalovirus in patients with acute Epstein-Barr virus infection. Europ. J. Clin. Microbiol. Infect. Dis., 19: 557-560, 2000.
    14. Rawlinson WD. Broadsheet number 50 : Diagnosis of human cytomegalovirus infection and disease. Pathology,31 : 109-115,1999.
    15. Chakravarti A, Kashyap B, Wadhwa A. Relationship of IgG avidity and IgM levels for the differential diagnosis of primary from recurrent cytomegalovirus infections. Iran J Allergy Asthma Immunol 2007; 684) : 197-201.
    16. Grangeot-Keros L, Mayaux MJ, Lebon P. et al.. Value of cytomegalovirus IgG avidity index for the diagnosis of primary CMV infection in pregnant women. J. Infect. Dis. 175 : 944-966,1997.
  • Product Code: YB500037
  • Number of Tests: 50
  • Sample Type: Serum Plasma
  • Sample Volume: 10 µl
  • Assay Range: N/A
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CMV IgG Avidity

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