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CMV IgG Avidity

Product Description

The CMV IgG test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers, for quantitative determination of specific IgG class antibodies directed against Cytomegalovirus virus in samples of human serum or plasma (K3-EDTA, Sodium Citrate).

This assay is used as a diagnostic aid when assessing immunity status of patients related to CMV (Cytomegalovirus) infection.

  • Complete panel for the diagnosis of the CMV infection, including CMV IgG, IgM and IgG Avidity
  • Significant sensitivity in the primary infection for both IgG and IgM tests
  • The high specificity of the IgM test allows the observation of the decreasing IgM concentration three months after the onset of the infection
  • The IgM titer decrease is correlated to the increasing value of the IgG avidity index
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    8. Lazzarotto T,Gabrielli L, Lanari M, Guerra B, Bellucci T, Sassi M, Landini MP. Congenital cytomegalovirus infection: recent advances in the diagnosis of maternal infection. Hum. Immunol. 2004 May; 65(5) : 410-415.
    9. Van De Meer JTM, Drew WL, Bowden RA et al. Summary of the international consensus symposium on advances in the diagnosis, treatment and prophylaxis of cytomegalovirus infection. Antivir. Res., 32: 119-140,1996.
    10. Lazzarotto T, Spezzacatena P, Pradelli P. et al. Avidity of immunoglobulin G directed again human cytomegalovirus during primary and secondary infections in immunocompetent and immnucompromised patients. Clin. Diagn. Lab. Immunol., 4: 469-473, 1997.
    11. Söderberg-Nauclé C, Fish KN, Nelson JA. Reactivation of latent human cytomegalovirus by allogenic stimulation of blood cells from healthy donors. Cell 1997; 91:119.
    12. Ross SA, Arora N, Novak Z, et al. Cytomegalovirus reinfections in healthy seroimmune women. J Infect Dis 2010; 201:386.
    13. Deyi YM, Goubau P, Bodéus M. False positive IgM antibody tests for cytomegalovirus in patients with acute Epstein-Barr virus infection. Europ. J. Clin. Microbiol. Infect. Dis., 19: 557-560, 2000.
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    15. Chakravarti A, Kashyap B, Wadhwa A. Relationship of IgG avidity and IgM levels for the differential diagnosis of primary from recurrent cytomegalovirus infections. Iran J Allergy Asthma Immunol 2007; 684) : 197-201.
    16. Grangeot-Keros L, Mayaux MJ, Lebon P. et al.. Value of cytomegalovirus IgG avidity index for the diagnosis of primary CMV infection in pregnant women. J. Infect. Dis. 175 : 944-966,1997.

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CMV IgG Avidity


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