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Bone Slices

Product Description

Bone slices are for accurate in vitro assessment of osteoclastic bone resorption either by traditional staining or by use of the CrossLaps® for Culture (CTX-I) ELISA assay.

  • Provides a suitable mineralised substrate for cultured osteoclasts to excavate authentic resorption lacunae
  • Allows the in vitro quantification of bone resorption when using an appropriate assay
  • Permits several samplings to be obtained from the same bone slice, allowing for example, reversibility measurement of osteoclast activity in response to given compounds
    1. Karsdal MA et al., Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression. J Biol Chem. 2003 Nov 7;278(45):44975-87.
    2. Schaller S et al., The chloride channel inhibitor NS3736 prevents bone resorption in ovariectomised rats without changing bone formation. J Bone Miner Res. 2004 Jul; 19(7):1144-53.

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Bone Slices


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