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CrossLaps® for Culture (CTX-I) ELISA

Product Description

For determination of bone related degradation products from C-terminal telopeptides of type I collagen in bone cell culture supernatant.

  • Supports the screening of early phase anti-resorptive drug development1-3
  • Allows high throughput screening of osteoclastic resorptive activity
  • Enables multiple testing of single osteoclast cultures over time
  • Objective assessment of in vitro bone resorption
  • High correlation to resorption pit area
  • Allows dynamic monitoring of bone cultures
  • Easy to perform – one step incubation
  • Part of a complete assay panel supporting bone research
    1. Burgeson RE. New collagens, new concepts. Annu Rev Cell Biol (1988);4:551-77.
    2. Stroup et al. Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate. J Bone Miner Res (2001);16:1739-1746
    3. Breuil et al. Human osteoclast formation and activity in vitro: effects of alendronate. J Bone Miner Res (1998);13:1721-1729

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CrossLaps® for Culture (CTX-I) ELISA


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