Cartilage Metabolism Markers for use in Translational Research
Immunodiagnostic Systems Limited (referred to hereafter as IDS) offers the most promising markers according to BIPED criteria to analyse cartilage related events in body fluids or tissues.1 Rosseau & Delmas1 used the BIPED (i.e. burden of disease, investigative, prognostic, efficacy of intervention and diagnostic) classification of Osteoarthritis (OA) markers to describe the potential usage of a given marker and concluded that the collagen type II degradation marker CTX-II seems to be the most promising marker.
Cartilage is a connective tissue found in many areas of the body, including joints between bones (articular cartilage). Individuals whose cartilage is affected suffer from joint disease (arthritis) which is mainly degenerative and causes arthritis/osteoarthritis (OA), but also inflammatory arthritis including rheumatoid arthritis (RA) and ankylosing spondylitis (AS).
For the quantification of degradation products of C-terminal telopeptides of type II collagen (CTX-II), assays are available for human urine, tissue culture supernatant, animal serum and synovial fluid. Cartilage turnover can be investigated with cartilage oligomeric matrix protein (COMP) in serum and synovial fluid in human and animal samples with the respective assay. Both CTX-II and COMP have been investigated as being useful in many published cohorts and studies.2
IDS is committed to providing highly accurate and reproducible assays, thus ensuring reliability of the results. Find out more about our Cartilage Markers product panel by visiting the product pages below:
1. Rousseau JC1, Delmas PD.Biological markers in osteoarthritis. Nat Clin Pract Rheumatol. 2007 Jun; 3(6):346-56.
2. Valdes AM et al., Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis. Osteoarthritis Cartilage. 2014 May;22(5):683-9.