• Traceable against the WHO 2nd International Standard for Human IgE 75/502
  • Well correlated to the market leader
  • Part of a growing allergy assay panel
  • Fully automated

An automated assay for the quantitative determination of Total IgE in human serum on the IDS System. The results are to be used as an aid in the diagnosis and management of allergic disorders in conjunction with other clinical findings.

Total IgE levels in serum are at the lowest concentration of any of the five human immunoglobulin isotypes and can be elevated in patients suffering from allergic conditions, e.g. allergic rhinitis, extrinsic asthma, or atopic dermatitis. Other conditions that are associated with increased Total IgE include parasite infections, ABPA (Allergic bronchopulmonary aspergillosis), IgE myeloma and hyper IgE (1, 2). An elevated total IgE level should stimulate further investigations for specific IgE sensitivity. A total serum IgE level is required to identify patients suffering from allergic asthma and urticaria that would benefit from therapy with antihuman IgE (3).

  1. Analytical Performance Characteristics, Quality Assurance, and Clinical Utility of Immunological Assays for Human Immunoglobulin E Antibodies of Defined Allergen Specificities. 3rd ed. CLSI report. I/LA20. Wayne, PA: Clinical Laboratory and Standards Institute, 2016
  2. Pawankar R, Canonica GW, Holgate ST, Lockey RF eds. WAO White Book on Allergy (Milwaukee: World Allergy Organization), 2011.
  3. Busse W, Corren J, Lanier BQ, McAlary M, Fowler-Taylor A, Cioppa GD, van As A, Gupta N. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol. 2001 Aug;108(2):184-90.
  • IDS Total IgE Control Set
  • IDS Specific IgE allergens for different indications