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IDS-iSYS Salivary Cortisol

Product Description

The IDS-iSYS Salivary Cortisol assay is intended for the quantitative determination of cortisol in human saliva on the IDS-iSYS Multi-Discipline Automated System family. Results are to be used as an aid in the assessment of Cushing’s and other disorders of the hypothalamic pituitary adrenal axis.

  • The assay is fully automated, with less than 8 minutes time to first results, allowing you to efficiently provide accurate biologically active plasma free cortisol results
  • The assay calibrators are traceable to an isotope dilution-mass spectrometry (ID-MS), from the Reference Institute for Bioanalytics (
  • The assay has excellent precision, functional sensitivity (0.02 µg/dL) and a wide assay measurable range (0.02-3.00µg/dL), giving you further confidence in the quality of assay results
    1. John J. Bray et al. Lecture notes on human physiology. Third Edition Published by Blackwell Science 1994.
    2. David W., The Immunoassay Handbook. Third Edition. D.Wild (Ed.) Published by Elsevier Ltd. 2005.
    3. Yaneva M., Mosnier-Pudar H., Dugue M-A., Grabar S., Fulla Y. and Bertagna X., ‘Midnight salivary cortisol for the initial diagnosis of Cushing’s and various causes’. J Clin Endocrinol Metab, 89(7), 2004, pp 3345-3351.
    4. Aardal, E. and Holm, A-C., ‘Cortisol in saliva – reference ranges and relation to cortisol in serum’. Eur J Clin Chem Clin Biochem, 33, 1995, 927-932.
    5. Rossi GP., Seccia TM. and Pessina AC., ‘Clinical use of laboratory tests for the identification of secondary forms of arterial hypertension’. Crit Rev Clin Sci, 44(1), 2007, pp 1-85.
    6. Nieman LK., Biller BMK., Findling JW., Newell-Price J., Savage MO., Stewart PM., and Montori VM., ‘The diagnosis of Cushing’s: an endocrine society clinical practice guideline’. J Clin Endocrinol Metab, 93, 2008, pp 1526-1540.
    7. Raff, H., ‘Cushing’s: diagnosis and surveillance using salivary cortisol’. Pituitary, 15, 2012, pp 64-70.
    8. Raff, H., ‘Update on late-night salivary cortisol for the diagnosis of Cushing’s: methodological considerations’. Endocrine, 44, 2013, pp 346-349.

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IDS-iSYS Salivary Cortisol


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