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Product Description

The IDS-iSYS ACTH assay is an in vitro diagnostic device intended for the quantitative determination of adrenocorticotropic hormone (ACTH) in human plasma on the IDS‑iSYS Multi-Discipline Automated System.

Results are to be used in conjunction with other clinical and laboratory data for the assessment of pituitary and adrenal gland function, the differential diagnosis of hyper- and hypo-cortisolism, as well as the evaluation of causes of endocrine hypertension.

The IDS ACTH assay:

  • is fully automated, with excellent precision and a functional sensitivity of 4.8pg/mL, allowing you to provide accurate results for ACTH concentrations in plasma samples
  • has a wide assay range up to 1000pg/mL, allowing maximum number of samples to be run directly without the need for dilution
  • has excellent correlation to other commercially available methods
  • has low levels of cross-reactivity to an extensive list of potentially interfering substances
  • is an effective tool in the assessment of pituitary and adrenal function, Cushing’s syndrome and Addison’s disease
    1. Schwyzer, R. ACTH: a short introductory review. Annals of the New York Academy of Sciences 297, 3-26 (1977).
    2. Raff, H. & Findling, J. W. A physiologic approach to diagnosis of the Cushing syndrome. Annals of Internal Medicine 138, 980-991 (2003).
    3. Talbot, J. A., Kane, J. W. & White, A. Analytical and clinical aspects of adrenocorticotrophin determination. Annals of Clinical Biochemistry 40, 453-471, (2003).
    4. White, A. & Gibson, S. ACTH precursors: biological significance and clinical relevance. Clinical Endocrinology 48, 251-255 (1998).
    5. Ray, D. W. et al. Elevated levels of adrenocorticotropin (ACTH) precursors in post-adrenalectomy Cushing’s disease and their regulation by glucocorticoids. The Journal of Clinical Endocrinology and Metabolism 80, 2430-2436, (1995).
    6. Stewart, P. M. et al. ACTH precursors characterize the ectopic ACTH syndrome. Clinical Endocrinology 40, 199-204 (1994).
    7. Lacroix, A., Feelders, R. A., Stratakis, C. A. & Nieman, L. K. Cushing’s syndrome. Lancet 386, 913-927, (2015).
    8. Arnaldi, G. et al. Diagnosis and complications of Cushing’s syndrome: a consensus statement. The Journal of Clinical Endocrinology and Metabolism 88, 5593-5602, (2003).
    9. Charmandari, E., Nicolaides, N. C. & Chrousos, G. P. Adrenal insufficiency. Lancet 383, 2152-2167, (2014).
    10. Bancos, I., Hahner, S., Tomlinson, J. & Arlt, W. Diagnosis and management of adrenal insufficiency. The Lancet. Diabetes & Endocrinology 3, 216-226, (2015).
    11. Arlt, W. & Allolio, B. Adrenal insufficiency. Lancet 361, 1881-1893, (2003).
    12. Nussey, S. S. et al. Isolated congenital ACTH deficiency: a cleavage enzyme defect? Clinical Endocrinology 39, 381-385 (1993).

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