β2-Glycoprotein I IgM
Product Description
The β2-Glycoprotein I IgM test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers. It is used for the quantitative determination of the specific IgM antibodies directed against β2-glycoprotein I in human samples of serum or plasma (EDTA and Heparin).
-
- Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. J Thromb Haemost 2006; 4:295-306.
- Pangborn MC. A new serologically active phospholipid from beef heart. Proc Soc Exp Biol & Med (NY) 1941; 48:484-486.
- Harris EN, Gharavi AE, Boey ML, Patel BM, Mackworth-Young CG, Loizou S, and Hughes GR. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983; 2:1211-1214.
- Galli M, Comfurius P, Maassen C, Hemker HC, de Baets MH, van Breda-Vriesman PJC, et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 1990; 335:1544-1547.
- McNeil HP, Simson RJ, Chesterman CN, and Krilis SA. Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation : β2-glicoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 1990; 87:4120-4127.
- Wurm H, Beubler E, Polz E, Holasek A, and Kostner G. Studies on the possible function of beta 2-glycoprotein-I: influence in the triglyceride metabolism in the rat. Metabolism 1982; 31:484-486.
- Nimpf J, Wurm H, Kostner GM. Interaction of beta 2-glycoprotein-I with human blood platelets: influence upon the ADP-induced aggregation. Thromb Haemost 1985; 54:397-401.
- Nimpf J, Bevers EM, Boman PH, Till U, Wurm H, Kostner GM, et al.. Prothrombinase activity of human platelets is inhibited by beta 2-glycoprotein-I. Biochim Biophys Acta 1986; 884:142-149.
- Balasubramanian K, Chandra J, Schroit AJ. Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta 2-glycoprotein I in macrophage recognition. J Biol Chem 1997; 272: 31113-31117.
- Bouma B, de Groot PG, van den Elsen JM, Ravelli RBG, Schouten A, Simmelink M, Derksen RHWM, Kroon J, and Gros P. Adhesion mechanism of human β2-Glicoprotein I to phospholipids based on its crystal structure. EMBO J 1999; 18:5166-5174.
- Schwarzenbacher R, Zeth K, Diederichs K, Gries A, Kostner GM, Laggner P, and Prassi R. Crystal structure of human β2-glycoprotein I: Implications for phospholipid binding and the antiphospholipid syndrome. EMBO J 1999; 18:6228-6239.
- Hunt J and Krilis S. The fifth domain of beta 2-glycoprotein I contains a phospholipid binding site (Cys281-Cys 288) and a region recognized by anticardiolipin antibodies. J Immunol 1994; 152:653-659.
- Matsuura E, Igarashi Y, Fujimoto M, Ichikawa K, and Koike T. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet, 1990; 336:177-178.
- Koike T and Matsuura E. What is the “true” antigen for anticardiolipin antibodies? Lancet 1991; 337:671-672.
- Matsuura E, Igarashi Y, Fujimoto M, Ichikawa K, Suzuki T, Sumida T, Yasuda T, and Koike T. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol, 1992; 148:3885-3891.
- Viard JP, Amoura Z, and Bach JF. Association of anti-β2-glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic anticoagulant and thrombosis in systemic lupus erythematosus. Am J Med, 1992; 93:181-186.
- Product Code: IS-AI1602
- Number of Tests: 100
- Sample Type: Serum Plasma
- Sample Volume: 6 µL
- Assay Range: 0-300 AU/mL
- Add to Enquiry Basket
Interested? Enquire now.
Add to Enquiry Basket
Related Products
| Assays | Certification | Platform | Clinical Area | Portfolio | RUO/IVD |
|---|---|---|---|---|---|
| β2-Glycoprotein I IgG | CE Marked | i10iSYS | Anti-Phospholipid SyndromeVasculitis | Autoimmunity | IVD |