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Product Description

The GBM test is a chemiluminescent immunoassay (CLIA), for use on IDS automated analyzers. It is used for the quantitative determination of the specific IgG antibodies directed against the Glomerular Basement Membrane (GBM), in human samples of serum or plasma (EDTA, sodium citrate).

    1. Lerner RA, Glassock RJ, Dixon FJ, The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med 1967; 126: 989-1004.
    2. Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG. Alport’s syndrome, Goodpasture’s syndrome, and type IV collagen. N Engl J Med 2003; 348: 2543-56.
    3. Levy JB, Turner AN, Rees AJ, Pusey CD. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma-exchange and immunosuppression. Ann Int Med 2001; 134: 1033-42.
    4. Wilson CB, Dixon FJ. Diagnosis of immunopathologic renal disease. Kidney Int 1974; 5: 389-401.
    5. Sinico RA, Radice A, Corace C, Sabadini E. Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: a comparison of different assays. Nephrol Dial Transplant 2006; 21: 397-401.
    6. Mahler M, Radice A, Sinico RA, Damoiseaux J, Seaman A, Buckmelter K et al. Performance evaluation of a novel chemiluminescence assay for detection of anti-GBM antibodies: an International multicenter study. Nephrol Dial Transplant 2012; 27 (1): 243-52.
    7. Segelmark M, Hellmark T, Wieslander J. The prognostic significance in Goodpasture’s disease of specificity, titre and affinity of anti-glomerular-basement membrane antibodies. Nephron Clin Pract 2003; 94: 59-68.
    8. Hellmark T, Niles JL, Collins AB, McCluskey RT, Brunmark C. Comparison of anti-GBM antibodies in sera with or without ANCA. J Am Soc Nephrol 1997; 8: 376-85.
    9. Levy JB, Hammad T, Coulthart A, Dougan T, Pusey CD. Clinical feature and outcome of patients with both ANCA and anti-GBM antibodies. Kidney Int 2004; 66: 1535-40.

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