- Animal Models of Rheumatoid Arthritis and Osteoarthritis:
- Easy, non-invasive quantification of cartilage degradation1
- Strong association to indexes of joint damage2
- Early response in COMP is highly correlated to histological endpoints
- COMP is elevated in both RA and OA rat models
- COMP levels are associated with disease activity in RA and OA3
- Useful for dynamic monitoring of cartilage in multiple species
- A complete assay panel supporting bone and cartilage research
Animal COMP® ELISA provides a method for the determination of Cartilage Oligomeric Matrix Protein (COMP) in Rat, Mouse, Sheep, Bovine, Pig and Goat serum.
COMP is a protein which is released in the blood when cartilage is destroyed and can be used prognostically for cartilage destruction in inflammatory joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA).
A quantitative relation between COMP concentration in serum and the degree of cartilage destruction has been shown.
(1) Larsson E et al., Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP. Rheumatology (Oxford). 2004 Apr;43(4):428–434.
(2) Larsson E et al., Serum concentrations of cartilage oligomeric matrix protein, fibrinogen and hyaluronan distinguish inflammation and cartilage destruction in experimental arthritis in rats. Rheumatology (Oxford). 2002 Sep;41(9):996-1000.
(3) Larsson E et al., Increased serum levels of cartilage oligomeric matrix protein and bone sialoprotein in rats with collagen arthritis. Br J Rheumatol. 1997 Dec;36(12):1258-61.