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Industry News

30/03/10

Welcome to the IDS Industry News section.  Here you will find many research papers and articles emerging in the areas of Bone, Growth and Cartilage disease. 

This section will be updated on a regular basis so be sure to keep visiting to find out about the latest developments in these rapidly growing areas of science.

Vitamin D Testing: How Will We Get it Right? 

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Short-Term Changes in Serum PINP Predict Long-Term Changes in Trabecular Bone in the Rat Ovariectomy Model.

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Secreted Tartrate-Resistant Acid Phosphatase 5b is a Marker of Osteoclast Number in Human Osteoclast Cultures and the Rat Ovariectomy Model

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Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe

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Ecological Studies Of Ultraviolet B, Vitamin D And Cancer Since 2000.

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Vitamin D Treatment Tames Colon Cancer Cells

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Review Ties Low Vitamin D Levels to Heart Disease  

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Tibolone: uncoupling of bone and cartilage effects? 

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Benefit Of Vitamin D In Diabetes And Other Chronic Diseases  

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Wintertime Vitamin D Supplementation Inhibits Seasonal Variation of Calcitropic Hormones and Maintains Bone Turnover in Healthy Men

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Bones may weaken after weight loss surgery

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Scotland's Health Deficit: An explanation and a plan

Health Research Forum - Oliver Gillie
Research Forum Occasional Reports: No 3

Scotland has an extreme climate characterised by very little sunshine. Its people have low levels of vitamin D because most vitamin D comes from the effect of sun on skin. Scots also have high levels of chronic illness - among the highest in the world. Low levels of vitamin D are now known to be an important cause of chronic illness including cancer and heart disease. But vitamin D has received little or no attention from policy makers in Scotland.
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Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality

Harald Dobnig, MD; Stefan Pilz, MD; Hubert Scharnagl, PhD; Wilfried Renner, PhD; Ursula Seelhorst, MA; Britta Wellnitz, LLD; Ju¨ rgen Kinkeldei, DEng; Bernhard O. Boehm, MD; Gisela Weihrauch, MSc; Winfried Maerz, MD
Arch Intern Med. 2008;168(12):1340-1349

Low 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D levels are independently associated with all-cause and cardiovascular mortality. A causal relationship has yet to be proved by intervention trials using vitamin D.
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Serum 25-hydroxyvitamin D levels in early and advanced breast cancer.

C Palmieri, T MacGregor, S Girgis, D Vigushin
J Clin Pathol 2006;59:1334-1336

Serum levels of 25(OH)D are significantly higher in patients with early-stage breast cancer than in those with locally advanced or metastatic disease.
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Vitamin D Levels and Disease Status in Texas Patients With Systemic Lupus Erythematosus

AMITHA THUDI, MBBS; SU YIN, MD; AMY E. WANDSTRAT, PHD; QUAN-ZHEN LI, PHD;
NANCY J. OLSEN, MD
Am J Med Sci. 2008 Feb;335(2):99-104

The increased disease symptoms present in patients with very low levels of vitamin D suggests a role for supplementation with exogenous vitamin D to optimize therapeutic outcomes. However, the possibility that such treatment could lead to increased autoantibody levels requires further study.
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Maternal vitamin D status during pregnancy and child outcomes.

CR Gale, SM Robinson, NC Harvey, MK Javaid, B Jiang, CN Martyn, KM Godfrey, C Cooper and the Princess Anne Hospital Study Group
European Journal of Clinical Nutrition (2008) 62, 68-77

Exposure to maternal concentrations of 25(OH)-vitamin D in pregnancy in excess of 75 nmol/l does not appear to influence the child's intelligence, psychological health or cardiovascular system; there could be an increased risk of atopic disorders, but this needs confirmation in other studies.
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Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in Patients Referred to Coronary Angiography

Stefan Pilz, Harald Dobnig, Brigitte Winklhofer-Roob, Gunter Riedmu¨ ller, Joachim E. Fischer, Ursula Seelhorst, Britta Wellnitz, Bernhard O. Boehm, and Winfried Ma¨rz
Cancer Epidemiol Biomarkers Prev 2008;17(5). May 2008

The data suggest that low levels of 25(OH)D are associated with increased risk of fatal cancer in patients referred to coronary angiography and that the maintenance of a sufficient vitamin D status might therefore be a promising approach for the prevention and/or treatment of cancer.
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Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer-results of a large case-control study.

Sascha Abbas, Jakob Linseisen, Tracy Slanger, Silke Kropp, Elke Jonny Mutschelknauss1,Dieter Flesch-Janys and Jenny Chang-Claude.
Carcinogenesis 2008 29(1):93-99; doi:10.1093/carcin/bgm240

The findings strongly suggest a protective effect for post-menopausal breast cancer through a better vitamin D supply as characterized by serum 25(OH)D measurement, with a stronger inverse association in women with low serum 25(OH)D concentrations (<50 nM).
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Cell Defenses and the Sunshine Vitamin

Luz E. Tavera-Mendoza and John H. White
Scientific American, Nov 2007.

Scientists now recognize that vitamin D does much more than build strong bones and that many people are not getting enough of it. Is widespread D deficiency contributing to major illnesses?
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